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Prior knowledge test

Please, complete the following questionnaire about general HIV Clinical Topics.
This test has a purely informative purpose for the organization of the event. Your answers will not be taken into account when reviewing your candidacy as an attendee and/or fellow.

1. Regarding a two-drug regimen with dolutegravir + lamivudine in initial ART, which one is false?

---A. It has proven non-inferiority against dolutegravir + TDF/FTCB. Tolerability was similar to dolutegravir + TDF/FTCC. Resistance was uncommon but did occur with dolutegravir + lamivudineD. There was a benefit in kidney and bone safety with dolutegravir + lamivudine

2. Which one is not considered as a major component of the strategies to reduce HIV transmission?:

---A. Starting ART the sooner the better.B. Achieving an undetectable viral load in those treatedC. Widespread use of PrEP in those at riskD. Achieving a viral load <20 copies/mL instead of <50 copies/mL.

3. Which one is expected to constitute a silent liver epidemic among HIV-infected subjects in the upcoming years?

---A. Non-alcoholic steatohepatitisB. Hepatitis C virus infectionC. Hepatitis B virus infectionD. Autoimmune hepatitis

4. Regarding PrEP use, which one is false?

---A. Using generic TDF/FTC it is a cost-effective strategyB. Daily TDF/FTC is the only approved strategy so far in EU.C. It is associated with a reduction of sexually transmitted infectionsD. The efficacy in treatment adherent subjects is high

5. Regarding drug-drug interactions with ART, which one is false:

---A. They can be potentially severe and involve contraindicated drugsB. Clinically significant (potentially severe) drug interactions are common (>25%) among subjects using cobicistat.C. Interaction with the liver CYP450 enzyme complex is the most common pathway where interactions occurD. Integrase inhibitors can interact with medications containing iron or calcium at a gastric level.

6. Which one should you consider the most important unmet need in ART?

---A. An oral regimen administered once weeklyB. A subcutaneous regimen auto-administered monthly or bimonthly by the patientC. A viral remission allowing at least a quarterly treatment interruptionD. A preventative vaccine with a protective efficacy of at least a 50%

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